The Supreme form aliens are created by the Ultimatrix Infinity. Azmuth says that they are 5 times stronger than the Ultimate aliens, which are supposedly 10 times stronger than the originals. They first appeared in the Max Tate: Alien Z episode, I Am, Supreme!
The Supreme form aliens are created by the Ultimatrix Infinity by putting the specified aliens DNA in a pocket dimension where a mere second for us, is a billion years for them. The DNA evolves over the billion years and returns to the Ultimatrix Infinity. That alien is accessible from then on. The Ultimatrix Infinity can only make Supreme forms of aliens already accessible.
- Heat Wave is the first alien to get a Supreme form.